Authors: Kien Chai Ong, Kum Thong Wong

Year: 2015

Journal: Brain Pathology

DOI: 10.1111/bpa.12278

Summary#

This paper discusses the clinical manifestations and pathological features of Hendra virus (HeV) and Nipah virus (NiV), which cause severe and often fatal outbreaks in humans and animals.

Key Findings#

• Both HeV and NiV cause an acute encephalitic syndrome
• Pathological features include disseminated, multi-organ vasculopathy and parenchymal cell infection
• Both viruses can cause relapsing encephalitis

Methodology#

• Study Type: Review
• Geographic Focus: Australia, Malaysia, Bangladesh, India, Philippines
• Time Period: 1990s to present

Topics#

Epidemiology, Clinical, Virology

Relevance#

The paper provides insights into the pathogenesis of henipaviruses and their potential for future spillover events into human populations.