Authors: Birgit Nikolay, Gabriel Ribeiro dos Santos, Marc Lipsitch, Mahmudur Rahman, Stephen P. Luby, Henrik Salje, Emily S. Gurley, Simon Cauchemez
Year: 2021
Journal: Vaccine
DOI: 10.1016/j.vaccine.2021.08.027
Summary#
This paper investigates the feasibility of conducting a phase III Nipah vaccine trial in Bangladesh using simulations based on previous outbreaks.
Key Findings#
- Three vaccination study designs were compared: clustered randomized controlled trials (cRCT), stepped wedge trials (SWT) and randomized crossover trials (RxO).
- The cRCT design requires the largest sample size but offers the highest statistical power.
- The SWT and RxO designs have lower sample sizes but take longer to complete.
Methodology#
- Study Type: Simulation Study
- Sample Size: Not specified, depends on the study design
- Geographic Focus: Bangladesh
- Time Period: Previously observed NiV cases
Topics#
Epidemiology, Clinical, Virology
Relevance#
This paper addresses the feasibility of evaluating Nipah vaccine efficacy trials in a context where spillovers from the zoonotic reservoir are infrequent.