Authors: Sabahat Gazal, Neelesh Sharma, Sundus Gazal, Mehak Tikoo, Deep Shikha, Gulzar Ahmed Badroo, Mohd Rashid, Sung-Jin Lee
Year: 2024
Journal: Pathogens
DOI: 10.3390/pathogens11121419
Summary#
This paper discusses Nipah and Hendra viruses, which are deadly zoonotic paramyxoviruses with a case fatality rate of up to 75%. The authors emphasize the need for research on these viruses due to their extreme pathogenicity, pandemic potential, and lack of established antiviral therapeutics and vaccines.
Key Findings#
- Nipah and Hendra viruses belong to the genus henipavirus in the family Paramyxoviridae
- The natural reservoirs of NiV and HeV are bats (flying foxes) with asymptomatic infection
- In humans, NiV infections result in severe respiratory and neurological manifestations
- Nipah virus was first identified in Malaysia and Singapore and subsequent outbreaks have been reported in Bangladesh and India
- Due to its extreme pathogenicity, pandemic potential, and lack of established antiviral therapeutics and vaccines, research on henipaviruses is highly warranted
Methodology#
- Study Type: Review
Topics#
Virology, Epidemiology, Clinical
Relevance#
This paper is important for Nipah research as it highlights the potential pandemic threat and the need for antivirals or vaccines.