Authors: Barry Rockx, Katharine N. Bossart, Friederike Feldmann, Joan B. Geisbert, Andrew C. Hickey, Douglas Brining, Julie Callison, David Safronetz, Andrea Marzi, Lisa Kercher, Dan Long, Christopher C. Broder, Heinz Feldmann, Thomas W. Geisbert
Year: 2010
Journal: Journal of Virology
DOI: 10.1128/JVI.01163-10
Summary#
This paper introduces a new disease model of acute Hendra Virus infection in African green monkeys and evaluates the effectiveness of Ribavirin treatment.
Key Findings#
- Exposure of AGMs to HeV produced a uniformly lethal infection.
- Ribavirin treatment delayed disease onset by 1 to 2 days, with no significant benefit for disease progression and outcome.
Methodology#
- Study Type: Experimental
- Sample Size: 9 African green monkeys (AGMs)
Topics#
Virology, African Green Monkeys, Ribavirin
Relevance#
The study provides a new disease model for testing antiviral strategies against Hendra Virus and questions the effectiveness of Ribavirin as an effective standalone therapy.