Authors: Dima A. Hammoud, Margaret R. Lentz, Abigail Lara, Jordan K. Bohannon, Irwin Feuerstein, Louis Huzella, Peter B. Jahrling, Matthew Lackemeyer, Joseph Laux, Oscar Rojas, Philip Sayre ID, Jeffrey Solomon, Yu Cong, Vincent Munster, Michael R. Holbrook
Year: 2018
Journal: PLoS Negl Trop Dis
DOI: 10.1371/journal.pntd.0006978
Summary#
This paper investigates the effects of aerosol exposure to intermediate size Nipah virus particles on African green monkeys, mimicking potential human exposure, and finds that it induces neurological disease.
Key Findings#
- Aerosol exposure using an intermediate particle size (7μm) was used to mimic potential human exposure by facilitating virus deposition in the upper respiratory tract
- Computed tomography evaluation found some animals developed pulmonary parenchymal disease
Methodology#
- Study Type: Experimental (African green monkey model)
- Sample Size: N/A
Topics#
Virology, Clinical, Epidemiology
Relevance#
This study provides important insights into the potential human exposure and effects of Nipah virus.