Authors: Kai Xu, Christopher C. Broder, Dimitar B. Nikolov
Year: 2012
Journal: Semin Cell Dev Biol
DOI: 10.1016/j.semcdb.2011.12.005
Summary#
This paper reviews recent progress in the study of henipavirus entry, particularly the identification of ephrins as their entry receptors, and the structural characterization of the ephrin/Henipa-G interactions.
Key Findings#
- Ephrin-B2 and -B3 identified as entry receptor for henipaviruses
- Nipah virus (NiV) and Hendra virus (HeV) use ephrins as their entry receptors
Methodology#
- Study Type: Review
Topics#
Virology, Epidemiology
Relevance#
The identification of ephrins as entry receptors for henipaviruses has implications for understanding the viral entry process and potentially developing anti-viral drugs.