Authors: Michael K. Lo, Jessica R. Spengler, Stephen R. Welch, Jessica R. Harmon, JoAnn D. Coleman-McCray, Florine E. M. Scholte, Punya Shrivastava-Ranjan, Joel M. Montgomery, Stuart T. Nichol, Drew Weissman, Christina F. Spiropoulou
Year: 2024
Journal: The Journal of Infectious Diseases
DOI: 10.xxxx/xxxxx
PMID: PMID or null
Summary#
A single-dose mRNA vaccine protected up to 70% of Syrian hamsters from lethal Nipah virus challenge, despite animals having suboptimally primed immune responses before challenge.
Key Findings#
- A single dose of the mRNA vaccine protected up to 70% of Syrian hamsters from lethal Nipah virus challenge
- Animals had suboptimally primed immune responses before challenge
Methodology#
- Study Type: Animal Study
- Sample Size: Syrian Hamsters
- Geographic Focus: Atlanta, Georgia, USA and Philadelphia, Pennsylvania, USA
- Time Period: 2024
Topics#
Vaccine Development, Nipah Virus, mRNA Vaccines
Relevance#
The study provides a foundation for optimizing future mRNA vaccination studies against Nipah virus and other highly pathogenic viruses.