Authors: Said Mougari, Claudia Gonzalez, Olivier Reynard, Branka Horvat
Year: 2022
Journal: Current Opinion in Virology
DOI: 10.1016/j.coviro.2022.101228
Summary#
This paper reviews the mechanisms that allow fruit bats to control Henipavirus infection while avoiding uncontrollable virus expansion and immunopathology.
Key Findings#
- Bats are the natural reservoir host for highly pathogenic Henipaviruses, including Hendra and Nipah viruses.
- Despite being infected, bats present limited signs of disease but can transmit the infection to other hosts, posing a risk for new viral outbreaks.
- Bats have evolved mechanisms permitting efficient control of Henipavirus infection, balancing viral tolerance and antiviral defense.
Methodology#
- Study Type: Review
Topics#
Epidemiology, Virology
Relevance#
This paper provides insights into the mechanism of bat coexistence with highly pathogenic Henipaviruses, which are known to cause serious human diseases.