Authors: M.Z. Rahman, M.M. Islam, M.E. Hossain, M.M. Rahman, A. Islam, A. Siddika, M.S.S. Hossain, S. Sultan, A. Islam, M. Rahman, M. Rahman, J.D. Klena, M.S. Flora, P. Daszak, J.H. Epstein, S.P. Lubye, E.S. Gurley
Year: 2021
Journal: International Journal of Infectious Diseases
Summary#
This study aimed to characterize the molecular epidemiology and evolution of Nipah virus in Bangladesh.
Key Findings#
- NiV-RNA was detected in 19% of bat roost urine samples.
- Nine N gene sequences were recovered from bat samples.
- Sequences were retrieved from 53% of archived RNA samples from patients.
- Phylogenetic analysis revealed that all Bangladeshi strains belonged to NiV-BD genotype.
- The analyses suggested that the strains of NiV-BD genotype diverged during 1995 and formed two sublineages.
Methodology#
- Study Type: Molecular detection, genetic characterization, Bayesian time-scale evolution analyses
- Sample Size: 456 bat roost urine samples and archived RNA samples from patients during 2012–2018 in Bangladesh
- Geographic Focus: Bangladesh
- Time Period: 2012–2018
Topics#
Nipah virus, Genetic characterization, Phylogenetics, Evolution
Relevance#
This research provides evidence of the evolution of Nipah virus strains in Bangladesh, highlighting the importance of continued surveillance to explore strain diversity and virulence potential.