Authors: Manuscript Author: Olivier Pernet, Manuscript Author: Benhur Lee
Year: 2012
Journal: Curr Top Microbiol Immunol.
DOI: 10.1007/82_2012_222
Summary#
This paper reviews the biology of the henipavirus receptors, ephrin-B2 and ephrin-B3, and how their usage relates to henipavirus cell tropism in vitro and in vivo.
Key Findings#
- Henipaviruses use ephrin-B2 and ephrin-B3 as viral entry receptors
- These receptors account for the unusual species tropism of henipaviruses
Methodology#
- Study Type: Review
Topics#
Virology
Relevance#
This paper provides insights into the receptor usage and tropism of henipaviruses, which are biosafety level 4 (BSL4) pathogens with high mortality rates in humans. Understanding these aspects can help develop vaccines and therapeutics for these deadly viruses.