Authors: Syed Moinuddin Satter, Arifa Nazneen, Wasik Rahman Aquib, Sharmin Sultana, Mohammed Ziaur Rahman, John D. Klena, Joel M. Montgomery, Tahmina Shirin
Year: 2023
Journal: Tropical Medicine and Infectious Disease
DOI: 10.3390/tropicalmed8010016
Summary#
This paper describes the first confirmed case of vertical transfer of humoral immunity against Nipah virus from a mother to her newborn in Bangladesh.
Key Findings#
- The mother and daughter from Faridpur district of Bangladesh were infected with Nipah virus, with the daughter passing away and the mother surviving with neurological impairment.
- Despite testing negative for anti-Nipah IgM and PCR for NiV, a high titre of anti-Nipah IgG was observed in the newborn.
- The transfer of humoral immunity against Nipah virus from mother to neonate was confirmed.
Methodology#
- Study Type: Case Study
- Geographic Focus: Faridpur district, Bangladesh
- Time Period: January 2020
Topics#
Nipah Virus, Immunology, Case Study
Relevance#
This study provides important insights into the transfer of NiV-specific antibodies through the placenta, potentially protecting newborns and influencing vaccine recommendations.