Authors: Beatriz Escudero-Pérez, Alexandre Lalande, Cyrille Mathieu, Philip Lawrence
Year: 2023
Journal: Humans. Viruses
DOI: 10.3390/v15030599
Summary#
This paper reviews key host-pathogen interactions influencing zoonotic spillover potential and transmission in humans, with a focus on the Nipah virus and Ebola virus.
Key Findings#
- Key factors determining spillover potential include cellular and tissue tropism, virulence, and pathogenic characteristics of the pathogen, and the capacity to adapt and evolve within a novel host environment.
- The review highlights an emerging understanding of the importance of steric hindrance of host cell factors by viral proteins using a ‘flytrap’-type mechanism of protein amyloidogenesis for future antiviral therapies against emerging pathogens.
Methodology#
- Study Type: Review
Topics#
Epidemiology, Virology, Policy
Relevance#
The paper discusses strategies to prepare for and reduce the frequency of zoonotic spillover occurrences in order to minimize the risk of new outbreaks, particularly relevant for Nipah research.