Host–Pathogen Interactions Influencing Zoonotic Spillover Potential and Transmission in Humans

Authors: Beatriz Escudero-Pérez, Alexandre Lalande, Cyrille Mathieu, Philip Lawrence

Year: 2023

Journal: Humans. Viruses

DOI: 10.3390/v15030599

Summary

This paper reviews key host-pathogen interactions influencing zoonotic spillover potential and transmission in humans, with a focus on the Nipah virus and Ebola virus.

Key Findings

• Key factors determining spillover potential include cellular and tissue tropism, virulence, and pathogenic characteristics of the pathogen, and the capacity to adapt and evolve within a novel host environment.
• The review highlights an emerging understanding of the importance of steric hindrance of host cell factors by viral proteins using a ‘flytrap’-type mechanism of protein amyloidogenesis for future antiviral therapies against emerging pathogens.

Methodology

• Study Type: Review

Topics

Epidemiology, Virology, Policy

Relevance

The paper discusses strategies to prepare for and reduce the frequency of zoonotic spillover occurrences in order to minimize the risk of new outbreaks, particularly relevant for Nipah research.

Source

View the entire paper: File:Viruses-15-00599.pdf