Inference of Nipah virus evolution, 1999–2015

Authors: Shannon L.M. Whitmer, Michael K. Lo, Hossain M. S. Sazzad, Sara Zufan, Emily S. Gurley, Sharmin Sultana, Brian Amman, Jason T. Ladner, Mohammed Ziaur Rahman, Stephanie Doan, Syed M. Satter, Meerjady S. Flora, Joel M. Montgomery, Stuart T. Nichol, Christina F. Spiropoulou, John D. Klena

Year: 2021

Journal: Virus Evolution

DOI: 10.1093/ve/veaa062

Summary

Researchers generated 35 additional full-length genomic sequences of Nipah virus directly from human specimens and viral isolates in Bangladesh to study its temporal and geographic evolution. They observed two distinct clades that intermingled over time and space, but did not find significant branch or site-specific selection except for a single site in the Henipavirus L polymerase.

Key Findings

Generated 35 additional full-length genomic sequences of Nipah virus
Observed two distinct clades that intermingled geographically and temporally in Bangladesh
Did not observe significant branch or site-specific selection except for a single site in the Henipavirus L polymerase
Bangladesh 1 and 2 clades are differentiated by mutations in the polymerase, with additional mutations accumulating in the N, G, F, P, and L genes on external branches

Methodology

Study Type: Research Article
Geographic Focus: Bangladesh
Time Period: 1999–2015

Topics

Virus Evolution, Nipah virus, Selecti

Relevance

The research helps to understand the evolution of Nipah virus in Bangladesh, which is important for public health measures and surveillance techniques.

Source

View the entire paper: File:Veaa062.pdf