View source for Experimental Infection of Syrian Hamsters With Aerosolized Nipah Virus

'''Authors:''' Olivier Escaffre, Terence Hill, Tetsuro Ikegami, Terry L. Juelich, Jennifer K. Smith, Lihong Zhang, David E. Perez, Colm Atkins, Arnold Park, William S. Lawrence, Satheesh K. Sivasubramani, Jennifer E. Peel, Johnny W. Peterson, Benhur Lee, Alexander N. Freiberg

'''Year:''' 2024

'''Journal:''' The Journal of Infectious Diseases

'''DOI:''' 10.xxxx/xxxxx

=== Summary ===
This paper evaluates the infectivity and pathogenicity of aerosolized Nipah virus (NiV) in Syrian hamsters, demonstrating that they develop similar clinical manifestations to those previously described using liquid inoculum.

=== Key Findings ===
* Both NiV-Malaysia (NiV-M) and its recombinant expressing firefly luciferase (rNiV-FlucNP) had equivalent pathogenicity in hamsters, causing respiratory and neurological symptoms.
* The virus replication was predominantly initiated in the lower respiratory tract and delayed but intensely in the oronasal cavity and possibly the brain.

=== Methodology ===
* '''Study Type:''' Experimental
* '''Sample Size:''' Syrian Hamsters

=== Topics ===
Virology, Epidemiology, Clinical

=== Relevance ===
This study provides insights into the potential role of aerosols in Nipah virus transmission and pathogenesis.

=== Source ===
View the entire paper: [[File:jiy357.pdf]]