View source for Ribavirin Therapy for Nipah Virus Infection

'''Authors:''' Guillaume, Cantamin, Loth, Georges-Courbot, Lefeuvre, Maraianneau, Chua, Lam, Buckland, Deubel, Wild

'''Year:''' 2004

'''Journal:''' Journal of Virology

'''DOI:''' 10.1128/JVI.78.18.10211.2004

=== Summary ===
This paper presents a study on the effectiveness of ribavirin therapy in treating Nipah virus infection in mice and humans, contradicting a previous statement that ribavirin was ineffective based on limited data.

=== Key Findings ===
* In an open-label study, mortality was significantly lower in patients with Nipah virus encephalitis treated with ribavirin compared to controls (32% vs. 54%, P ⫽ 0.011)
* Duration of ventilation and total hospital stay were both significantly shorter in the ribavirin group compared to controls (P ⫽ 0.0002 and <0.0001, respectively)

=== Methodology ===
* '''Study Type:''' Open-label study
* '''Sample Size:''' 140 patients with Nipah virus encephalitis
* '''Geographic Focus:''' Malaysia
* '''Time Period:''' 1998

=== Topics ===
Virology, Clinical

=== Relevance ===
The paper challenges a previous misleading statement about the ineffectiveness of ribavirin in treating Nipah virus infection, providing important information for future research.

=== Source ===
View the entire paper: [[File:0864-04.pdf]]