Assessing the feasibility of Nipah vaccine eﬄiciency trials based on previous outbreaks in Bangladesh

Authors: Birgit Nikolay, Gabriel Ribeiro dos Santos, Marc Lipsitch, Mahmudur Rahman, Stephen P. Luby, Henrik Salje, Emily S. Gurley, Simon Cauchemez

Year: 2021

Journal: Vaccine

DOI: 10.1016/j.vaccine.2021.08.027

Summary

This paper investigates the feasibility of conducting a phase III Nipah vaccine trial in Bangladesh using simulations based on previous outbreaks.

Key Findings

Three vaccination study designs were compared: clustered randomized controlled trials (cRCT), stepped wedge trials (SWT) and randomized crossover trials (RxO).
The cRCT design requires the largest sample size but offers the highest statistical power.
The SWT and RxO designs have lower sample sizes but take longer to complete.

Methodology

Study Type: Simulation Study
Sample Size: Not specified, depends on the study design
Geographic Focus: Bangladesh
Time Period: Previously observed NiV cases

Topics

Epidemiology, Clinical, Virology

Relevance

This paper addresses the feasibility of evaluating Nipah vaccine efficacy trials in a context where spillovers from the zoonotic reservoir are infrequent.

Source

View the entire paper: File:Manuscript from vacc.pdf