In silico prediction of interaction between Nipah virus attachment glycoprotein and host cell receptors Ephrin-B2 and Ephrin-B3 in domestic and peridomestic mammals
Authors: Ananya Ferdous Hoque, Md. Mahfuzur Rahman, Ayeasha Siddika Lamia, Ariful Islam, John D. Klena, Syed Moinuddin Satter, Jonathan H. Epstein, Joel M. Montgomery, Mohammad Enayet Hossain, Tahmina Shirin, Iqbal Kabir Jahid, Mohammed Ziaur Rahman
Year: 2023
Journal: Infection, Genetics and Evolution
DOI: 10.1016/j.meegid.2023.105516
Summary
This paper investigates the binding affinity of Nipah virus attachment glycoprotein to host cell receptors Ephrin-B2 and Ephrin-B3 in domestic and peridomestic mammals commonly found in Bangladesh.
Key Findings
- NiV Bangladesh (NiV-B) strain displayed stronger binding to Ephrin receptors, especially with Ephrin-B3 compared to the NiV Malaysia (NiV-M) strain
- Ephrin receptors of domestic rat (R. norvegicus) had a higher binding affinity for NiV G, suggesting greater susceptibility to NiV infections compared to other study species
Methodology
- Study Type: In silico
- Sample Size: 52 NiV G complexes with Ephrin-B2 and B3 of 13 domestic and peridomestic species
- Geographic Focus: Bangladesh
Topics
Molecular docking, Protein-protein interaction, Nipah virus, Glycoprotein, Ephrin
Relevance
This study provides insights into the potential for domestic and peridomestic mammals to serve as intermediate hosts of Nipah virus, which could be crucial in transmission dynamics.
Source
View the entire paper: File:1-s2.0-S1567134823001144-main.pdf