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A Novel Model of Lethal Hendra Virus Infection in African Green Monkeys and the Effectiveness of Ribavirin Treatment

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Authors: Barry Rockx, Katharine N. Bossart, Friederike Feldmann, Joan B. Geisbert, Andrew C. Hickey, Douglas Brining, Julie Callison, David Safronetz, Andrea Marzi, Lisa Kercher, Dan Long, Christopher C. Broder, Heinz Feldmann, Thomas W. Geisbert

Year: 2010

Journal: Journal of Virology

DOI: 10.1128/JVI.01163-10

Summary

This paper introduces a new disease model of acute Hendra Virus infection in African green monkeys and evaluates the effectiveness of Ribavirin treatment.

Key Findings

  • Exposure of AGMs to HeV produced a uniformly lethal infection.
  • Ribavirin treatment delayed disease onset by 1 to 2 days, with no significant benefit for disease progression and outcome.

Methodology

  • Study Type: Experimental
  • Sample Size: 9 African green monkeys (AGMs)

Topics

Virology, African Green Monkeys, Ribavirin

Relevance

The study provides a new disease model for testing antiviral strategies against Hendra Virus and questions the effectiveness of Ribavirin as an effective standalone therapy.

Source

View the entire paper: File:1163-10.pdf

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