Nipah Open Library

Revolutionizing Nipah virus vaccinology: insights into subunit vaccine development strategies and immunological advances

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Authors: Tapas Das, Sutapa Datta, Arnab Sen

Year: 2024

Journal: In Silico Pharmacology

DOI: 10.1007/s40203-024-00246-9

Summary

The paper aims to develop a subunit vaccine against the Nipah virus (NiV) by analyzing its proteome and predicting T-cell, helper T-cell, and B-cell epitopes using various servers. The predicted high-affinity epitopes were evaluated for antigenicity, toxicity, and allergenicity, and molecular interactions with specific receptors were analyzed.

Key Findings

  • Subunit vaccine development strategies for NiV
  • Prediction of T-cell, helper T-cell, and B-cell epitopes
  • Evaluation of epitopes' antigenicity, toxicity, and allergenicity
  • Molecular interactions with specific receptors analyzed

Methodology

  • Study Type: In Silico Study

Topics

Vaccinology, Immunology

Relevance

This paper contributes to the development of a subunit vaccine against Nipah virus, which could become a superior preventive measure.

Source

View the entire paper: File:40203 2024 Article 246.pdf

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