Neurological pathophysiology of SARS-CoV-2 and pandemic potential RNA viruses: a comparative analysis
Authors: Nikhil Chakravarty, Thrisha Senthilnathan, Sophia Paiola, Priya Gyani, Sebastian Castillo Cario, Estrella Urena, Akash Jeysankar, Prakash Jeysankar, Joseph Ignatius Irudayam, Sumathi Natesan Subramanian, Helen Lavretsky, Shantanu Joshi, Gustavo Garcia Jr., Arunachalam Ramaiah, Vaithilingaraja Arumugaswami
Year: 2024
Journal: Not specified in text
DOI: 10.xxxx/xxxxx or null
PMID: PMID or null
Summary
This review paper discusses the abilities of SARS-CoV-2 and other neurotropic RNA viruses, including Zika virus and Nipah virus, to cross the blood–brain barrier into the central nervous system. It highlights the role of magnetic resonance imaging (MRI) in assessing presence and severity of brain structural changes in COVID-19 patients and presents new insight into key mutations in SARS-CoV-2 variants that may impact on neuropilin 1 binding and CNS invasion.
Key Findings
- SARS-CoV-2 can infect both peripheral cells capable of crossing the blood–brain barrier and brain endothelial cells to traverse the barrier and spread into the brain.
- Magnetic resonance imaging (MRI) can be used to better understand the long-term effects of COVID-19 on the brain.
Methodology
- Study Type: Review
- Sample Size: Not specified in text
- Geographic Focus: Multiple locations
- Time Period: Present day
Topics
Neurology, Virology, MRI
Relevance
This paper adds to the understanding of neurological symptoms associated with COVID-19 and the potential impact of SARS-CoV-2 variants on neuropilin 1 binding and central nervous system invasion.
Source
View the entire paper: File:FEB2-595-2854.pdf