Nipah Open Library

A comparative genomic approach to decipher the mutations associated with Nipah viral human isolates from southeast Asia

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Authors: Norine Norbert Dsouza, Selvaa Kumar Chellasamy

Year: 2024

Journal: Volume 16 Number 1 (February 2024) 104-113

Summary

This paper uses a comparative genomic approach to identify mutations in Nipah virus (NiV) human isolates from Malaysia, Bangladesh, and India.

Key Findings

  • NiV isolates were categorized into NiV-M, NiV-B, and NiV-I clades based on phylogenetic analysis
  • Metagenomic analysis revealed 1636 variations in the noncoding and coding regions of the genomes of the three clades of NiV
  • The phosphoprotein was found to be highly mutating, whereas the matrix protein was stable

Methodology

  • Study Type: Original Article
  • Sample Size: 37 NiV genomes of human samples
  • Geographic Focus: Malaysia, Bangladesh, and India

Topics

Nipah virus, Phylogeny, Mutations, Host-pathogen interaction

Relevance

The study provides valuable insights into the stability of NiV proteins, which can be useful for understanding variations in host-pathogen interactions and developing effective therapeutic measures.

Source

View the entire paper: File:IJM-16-104.pdf

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