Authors: M.Z. Rahman, M.M. Islam, M.E. Hossain, M.M. Rahman, A. Islam, A. Siddika, M.S.S. Hossain, S. Sultan, A. Islam, M. Rahman, M. Rahman, J.D. Klena, M.S. Flora, P. Daszak, J.H. Epstein, S.P. Lubye, E.S. Gurley
Year: 2021
Journal: International Journal of Infectious Diseases
Summary
This study aimed to characterize the molecular epidemiology and evolution of Nipah virus in Bangladesh.
Key Findings
- NiV-RNA was detected in 19% of bat roost urine samples.
- Nine N gene sequences were recovered from bat samples.
- Sequences were retrieved from 53% of archived RNA samples from patients.
- Phylogenetic analysis revealed that all Bangladeshi strains belonged to NiV-BD genotype.
- The analyses suggested that the strains of NiV-BD genotype diverged during 1995 and formed two sublineages.
Methodology
- Study Type: Molecular detection, genetic characterization, Bayesian time-scale evolution analyses
- Sample Size: 456 bat roost urine samples and archived RNA samples from patients during 2012–2018 in Bangladesh
- Geographic Focus: Bangladesh
- Time Period: 2012–2018
Topics
Nipah virus, Genetic characterization, Phylogenetics, Evolution
Relevance
This research provides evidence of the evolution of Nipah virus strains in Bangladesh, highlighting the importance of continued surveillance to explore strain diversity and virulence potential.
Source
View the entire paper: File:PIIS1201971220322451.pdf