Immunological correlates of protection afforded by PHV02 live, attenuated recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease

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Authors: Thomas P. Monath, Richard Nichols, Friederike Feldmann, Amanda Griffin, Elaine Haddock, Julie Callison, Kimberly Meade-White, Atsushi Okumura, Jamie Lovaglio, Patrick W. Hanley, Chad S. Clancy, Carl Shaia, Wasima Rida, Joan Fusco

Year: 2023

Journal: Front. Immunol.

DOI: 10.3389/fimmu.2023.1216225

Summary

This paper investigates immunological correlates of protection afforded by PHV02, a recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease in the African green monkey model. Neutralizing antibody to Nipah virus is proposed as the principal mediator of protection.

Methodology

  • Study Type: Original Research
  • Sample Size: Not specified in text
  • Geographic Focus: Not specified in text
  • Time Period: Not specified in text

Topics

Vaccine Development, Virology

Relevance

This paper provides insights into the immunological correlates of protection afforded by PHV02, a potential vaccine against Nipah virus disease. Further research could lead to the development of effective vaccines and interventions.

Source

View the entire paper: File:Fimmu-14-1216225.pdf