Nipah Open Library

Recombinant vesicular stomatitis virus–vectored vaccine induces long-lasting immunity against Nipah virus disease

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Authors: Courtney Woolsey, Viktoriya Borisevich, Alyssa C. Fears, Krystle N. Agans, Daniel J. Deer, Abhishek N. Prasad, Rachel O’Toole, Stephanie L. Foster, Natalie S. Dobias, Joan B. Geisbert, Karla A. Fenton, Robert W. Cross, Thomas W. Geisbert

Year: 2024

Journal: The Journal of Clinical Investigation

DOI: 10.xxxx/xxxxx

Summary

This paper reports on a recombinant vesicular stomatitis virus–based vaccine that provides long-lasting immunity against Nipah virus disease in African green monkeys.

Key Findings

  • rVSV-ΔG-NiVBG vaccine protects 100% of nonhuman primates from NiV-associated lethality within a week
  • All immunized AGMs (whether receiving a single dose or prime-boosted) survived with no detectable clinical signs or NiV replication
  • Transcriptomic analyses indicated that adaptive immune signatures correlated with vaccine-mediated protection

Methodology

  • Study Type: Experimental
  • Sample Size: African green monkeys (AGMs)
  • Geographic Focus: Galveston, Texas, USA

Topics

Vaccines, Nipah Virus, Immunology

Relevance

The development of a long-lasting immunity vaccine for Nipah virus could be crucial in preventing future outbreaks and pandemics.

Source

View the entire paper: File:Jci-133-164946.pdf

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