Nipah Virus Bangladesh Infection Elicits Organ-Specific Innate and Inflammatory Responses in the Marmoset Model
Authors: Christian S. Stevens, Jake Lowry, Terry Juelich, Colm Atkins, Kendra Johnson, Jennifer K. Smith, Maryline Panis, Tetsuro Ikegami, Benjamin tenOever, Alexander N. Freiberg, Benhur Lee
Year: 2023
Journal: The Journal of Infectious Diseases
DOI: 10.xxxx/xxxxx
Summary
This paper studies the susceptibility and pathogenesis of Nipah virus Bangladesh strain (NiVB) infection in marmosets at biosafety level 4. The study reveals unique transcriptomes in different tissues from infected and control marmosets, particularly in the brainstem of a marmoset that exhibited neurological signs.
Key Findings
- All 4 infected marmosets developed fatal disease
- Three developed pulmonary edema and hemorrhage as well as multifocal hemorrhagic lymphadenopathy
- One recapitulated neurological clinical manifestations and cardiomyopathy on gross pathology
- A unique transcriptome was revealed in the brainstem of the marmoset exhibiting neurological signs
Methodology
- Study Type: Experimental Study
- Sample Size: 4 marmosets
Topics
Nipah virus, Marmoset Model, Pathogenesis, Neurological Disease
Relevance
This study provides a more comprehensive understanding of NiV pathogenesis in an accessible and novel NHP model, closely reflecting clinical disease as observed in NiV patients.
Source
View the entire paper: File:Jiad053.pdf