Nipah Open Library

Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters

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Authors: Michael K. Lo, Jessica R. Spengler, Stephen R. Welch, Jessica R. Harmon, JoAnn D. Coleman-McCray, Florine E. M. Scholte, Punya Shrivastava-Ranjan, Joel M. Montgomery, Stuart T. Nichol, Drew Weissman, Christina F. Spiropoulou

Year: 2024

Journal: The Journal of Infectious Diseases

DOI: 10.xxxx/xxxxx

PMID: PMID or null

Summary

A single-dose mRNA vaccine protected up to 70% of Syrian hamsters from lethal Nipah virus challenge, despite animals having suboptimally primed immune responses before challenge.

Key Findings

  • A single dose of the mRNA vaccine protected up to 70% of Syrian hamsters from lethal Nipah virus challenge
  • Animals had suboptimally primed immune responses before challenge

Methodology

  • Study Type: Animal Study
  • Sample Size: Syrian Hamsters
  • Geographic Focus: Atlanta, Georgia, USA and Philadelphia, Pennsylvania, USA
  • Time Period: 2024

Topics

Vaccine Development, Nipah Virus, mRNA Vaccines

Relevance

The study provides a foundation for optimizing future mRNA vaccination studies against Nipah virus and other highly pathogenic viruses.

Source

View the entire paper: File:Jiz553.pdf

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