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Potent monoclonal antibody–mediated neutralization of a divergent Hendra virus variant

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Authors: Zhaoqian Wang, Ha V. Dang, Moushimi Amaya, Yan Xu, Randy Yin, Lianying Yan, Andrew C. Hickey, Edward J. Annand, Bethany A. Horsburgh, Peter A. Reid, Ina Smith, John-Sebastian Eden, Kai Xu, Christopher C. Broder, David Veesler

Year: 2022

Journal: Not specified in the text

DOI: 10.xxxx/xxxxx or null (not provided in the text)

PMID: PMID or null (not provided in the text)

Summary

This paper studies a new variant of Hendra virus (HeV-g2) that has unprecedented genetic divergence and identifies it in horses and flying fox species in Australia. The researchers demonstrate that HeV-g2 shares a conserved receptor tropism with prototypic HeV and can be potently neutralized by a panel of monoclonal antibodies recognizing the G and F glycoproteins.

Key Findings

  • The study identifies a new Hendra virus variant (HeV-g2) with unprecedented genetic divergence
  • HeV-g2 shares a conserved receptor tropism with prototypic HeV
  • A panel of monoclonal antibodies recognizing the G and F glycoproteins potently neutralizes HeV-g2– and HeV G/F– mediated entry into cells

Methodology

  • Study Type: Not specified in the text
  • Sample Size: Two fatally diseased horses and two flying fox species studied
  • Geographic Focus: Regions of Australia
  • Time Period: Not specified in the text

Topics

Virology, Immunology

Relevance

Understanding receptor usage and antigenic properties of HeV-g2 is urgently required to guide One Health biosecurity

Source

View the entire paper: File:Pnas.202122769.pdf

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