Authors: Sham Nambullia, Linda J. Rennick, Andrew S. Acciardo, Natasha L. Tilston-Lunel, Gregory Hoc, Nicholas A. Crossland, Kathy Hardcastle, Betsy Nieto, Graeme Bainbridge, Tracey Williams, Claire R. Sharp, W. Paul Dupre
Year: 2024
Journal: Journal Name not provided in the text
DOI: 10.xxxx/xxxxx or null (not provided in the text)
PMID: PMID or null (not provided in the text)
Summary
This paper investigates a newly discovered pathogen, Feline Morbillivirus (FeMV), affecting domestic cats. The study determines the complete sequence of FeMV and reveals unique characteristics that differ from other morbilliviruses. FeMV uses a different protease to furin for processing its fusion glycoprotein and employs feline CD150 as a cellular receptor, making it distinct among morbilliviruses. The study also develops a reverse genetics system for FeMV and demonstrates that it causes an acute morbillivirus-like disease in cats.
Key Findings
- FeMV lacks the canonical polybasic furin cleavage signal in the fusion (F) glycoprotein
- Conserved amino acids in the hemagglutinin (H) glycoprotein used by other morbilliviruses for binding and/or fusion activation with the cellular receptor CD150 are absent in FeMV
- FeMV H glycoprotein uses feline CD150 as a receptor and cannot use human CD150
- The protease responsible for cleaving the FeMV F glycoprotein is a cathepsin, making FeMV unique among morbilliviruses
- FeMV causes an acute morbillivirus-like disease in cats and sheds light on its possible role in the development of chronic kidney disease
Methodology
- Study Type: Experimental/Molecular Biology
- Sample Size: 1 unpassaged clinical isolate
- Geographic Focus: Not specified
- Time Period: Not specified
Topics
Virology, Epidemiology
Relevance
This paper investigates a newly discovered pathogen affecting domestic cats, which may be related to the etiology of feline chronic kidney disease, a leading cause of morbidity and mortality in cats.
Source
View the entire paper: File:Pnas.202209405.pdf