Aerosol exposure to intermediate size Nipah virus particles induces neurological disease in African green monkeys

Authors: Dima A. Hammoud, Margaret R. Lentz, Abigail Lara, Jordan K. Bohannon, Irwin Feuerstein, Louis Huzella, Peter B. Jahrling, Matthew Lackemeyer, Joseph Laux, Oscar Rojas, Philip Sayre ID, Jeffrey Solomon, Yu Cong, Vincent Munster, Michael R. Holbrook

Year: 2018

Journal: PLoS Negl Trop Dis

DOI: 10.1371/journal.pntd.0006978

Summary

This paper investigates the effects of aerosol exposure to intermediate size Nipah virus particles on African green monkeys, mimicking potential human exposure, and finds that it induces neurological disease.

Key Findings

• Aerosol exposure using an intermediate particle size (7μm) was used to mimic potential human exposure by facilitating virus deposition in the upper respiratory tract
• Computed tomography evaluation found some animals developed pulmonary parenchymal disease

Methodology

• Study Type: Experimental (African green monkey model)
• Sample Size: N/A

Topics

Virology, Clinical, Epidemiology

Relevance

This study provides important insights into the potential human exposure and effects of Nipah virus.

Source

View the entire paper: File:Pntd.0006978.pdf