Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy
Authors: Chad E. Mire, Benjamin A. Satterfield, Joan B. Geisbert, Krystle N. Agans, Viktoriya Borisevich, Lianying Yan, Yee-Peng Chan, Robert W. Cross, Karla A. Fenton, Christopher C. Broder, Thomas W. Geisbert
Year: 2016
Journal: Scientific Reports
DOI: 10.xxxx/xxxxx
Summary
This paper investigates the pathogenic differences between two strains of Nipah virus (NiV), Malaysia (NiVM) and Bangladesh (NiVB), by exposing African green monkeys to each strain. The findings suggest that NiVB is more pathogenic, with a higher mortality rate and more severe histopathology in infected animals compared to NiVM.
Key Findings
- NiVB is uniformly lethal while only 50% of NiVM-infected animals succumb to infection
- Histopathology of lungs and spleens from NiVB-infected AGMs is significantly more severe than NiVM-infected animals
- The therapeutic window for human monoclonal antibody m102.4, previously shown to rescue AGMs from NiVM infection, is much shorter in NiVB-infected AGMs
Methodology
- Study Type: Experimental
- Sample Size: 8 African green monkeys
- Geographic Focus: null
- Time Period: null
Topics
Virology, Epidemiology, Clinical
Relevance
These findings have implications for the development of strain-specific postexposure treatments for Nipah virus infections.
Source
View the entire paper: File:Srep30916.pdf