Authors: Shannon L.M. Whitmer, Michael K. Lo, Hossain M. S. Sazzad, Sara Zufan, Emily S. Gurley, Sharmin Sultana, Brian Amman, Jason T. Ladner, Mohammed Ziaur Rahman, Stephanie Doan, Syed M. Satter, Meerjady S. Flora, Joel M. Montgomery, Stuart T. Nichol, Christina F. Spiropoulou, John D. Klena
Year: 2021
Journal: Virus Evolution
DOI: 10.1093/ve/veaa062
Summary
Researchers generated 35 additional full-length genomic sequences of Nipah virus directly from human specimens and viral isolates in Bangladesh to study its temporal and geographic evolution. They observed two distinct clades that intermingled over time and space, but did not find significant branch or site-specific selection except for a single site in the Henipavirus L polymerase.
Key Findings
- Generated 35 additional full-length genomic sequences of Nipah virus
- Observed two distinct clades that intermingled geographically and temporally in Bangladesh
- Did not observe significant branch or site-specific selection except for a single site in the Henipavirus L polymerase
- Bangladesh 1 and 2 clades are differentiated by mutations in the polymerase, with additional mutations accumulating in the N, G, F, P, and L genes on external branches
Methodology
- Study Type: Research Article
- Geographic Focus: Bangladesh
- Time Period: 1999–2015
Topics
Virus Evolution, Nipah virus, Selecti
Relevance
The research helps to understand the evolution of Nipah virus in Bangladesh, which is important for public health measures and surveillance techniques.
Source
View the entire paper: File:Veaa062.pdf