Nipah Open Library

Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models

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Authors: Philip Lawrence, Beatriz Escudero-Pérez

Year: 2022

Journal: Viruses

DOI: 10.3390/v14050936

Summary

This review provides an overview of the pathogenicity mechanisms and interactions between Henipaviruses (Nipah and Hendra) and their hosts in various species including bats, pigs, horses, humans, and experimental animal models. The findings could aid in developing new therapeutic strategies against these re-emerging viruses.

Key Findings

  • Nipah henipavirus (NiV) and Hendra henipavirus (HeV) are highly pathogenic, zoonotic paramyxoviruses that infect a wide range of animals and humans.
  • Observed fatality rates for HeV and NiV in humans are up to 60% and 92%, respectively.

Methodology

  • Study Type: Review

Topics

Virology, Epidemiology

Relevance

Understanding the interactions between henipaviruses and their hosts could facilitate the development of new therapeutic strategies against these re-emerging viruses.

Source

View the entire paper: File:Viruses-14-00936.pdf

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