Authors: Guillaume, Cantamin, Loth, Georges-Courbot, Lefeuvre, Maraianneau, Chua, Lam, Buckland, Deubel, Wild
Year: 2004
Journal: Journal of Virology
DOI: 10.1128/JVI.78.18.10211.2004
Summary
This paper presents a study on the effectiveness of ribavirin therapy in treating Nipah virus infection in mice and humans, contradicting a previous statement that ribavirin was ineffective based on limited data.
Key Findings
- In an open-label study, mortality was significantly lower in patients with Nipah virus encephalitis treated with ribavirin compared to controls (32% vs. 54%, P ⫽ 0.011)
- Duration of ventilation and total hospital stay were both significantly shorter in the ribavirin group compared to controls (P ⫽ 0.0002 and <0.0001, respectively)
Methodology
- Study Type: Open-label study
- Sample Size: 140 patients with Nipah virus encephalitis
- Geographic Focus: Malaysia
- Time Period: 1998
Topics
Virology, Clinical
Relevance
The paper challenges a previous misleading statement about the ineffectiveness of ribavirin in treating Nipah virus infection, providing important information for future research.
Source
View the entire paper: File:0864-04.pdf