A systematic review on Nipah virus: global molecular epidemiology and medical countermeasures development
Authors: Foo Hou Tan1,‡, Asif Sukri2,‡, Nuryana Idris1,3, Kien Chai Ong 3,6, Kum Thong Wong 7, Jie Ping Schee3,5, Chong Tin Tan3,5, Soon Hao Tan4, Li Ping Wong, Kok Keng Tee, Li-Yen Chang 1,*
Year: 2024
Journal: Virus Evolution
DOI: 10.1093/ve/veae048
Summary
This paper conducts a systematic review on the global epidemiology and research advancements of Nipah virus, aiming to identify key knowledge gaps in the literature.
Key Findings
- The majority of the NiV epidemiological studies were conducted in Bangladesh, with significant outbreaks also reported in Malaysia, India, and the Philippines.
- Transmission routes vary by country, primarily through pigs in Malaysia, consumption of date palm juice in Bangladesh, and human-to-human in India.
- The availability of NiV genome sequences remains limited, particularly from Malaysia and India.
- Mortality rates vary according to the country, exceeding 70% in Bangladesh, India, and the Philippines, and less than 40% in Malaysia.
Methodology
- Study Type: Systematic Review
- Geographic Focus: Global
Topics
Epidemiology, Virology
Relevance
Understanding the differences in mortality rate among countries is crucial for informing Nipah virus epidemiology and enhancing outbreak prevention and management strategies.