Ephrin-B2 and ephrin-B3 as functional henipavirus receptors

Authors: Kai Xu, Christopher C. Broder, Dimitar B. Nikolov

Year: 2012

Journal: Semin Cell Dev Biol

DOI: 10.1016/j.semcdb.2011.12.005

Summary

This paper reviews recent progress in the study of henipavirus entry, particularly the identification of ephrins as their entry receptors, and the structural characterization of the ephrin/Henipa-G interactions.

Key Findings

Ephrin-B2 and -B3 identified as entry receptor for henipaviruses
Nipah virus (NiV) and Hendra virus (HeV) use ephrins as their entry receptors

Methodology

Study Type: Review

Topics

Virology, Epidemiology

Relevance

The identification of ephrins as entry receptors for henipaviruses has implications for understanding the viral entry process and potentially developing anti-viral drugs.

Source

View the entire paper: File:Nihms351212.pdf