Hendra and Nipah Infection: Pathology, Models and Potential Therapies

Authors: Frederic Vigant, Benhur Lee

Year: 2011

Journal: Infect Disord Drug Targets

DOI: 10.xxxx/xxxxx (not provided in text)

PMID: PMID not provided in text

Summary

This paper reviews the unique features of henipavirus infections, and discusses different strategies and animal models that have been developed to identify and test potential drugs for preventing or treating henipavirus infections.

Key Findings

Henipaviruses are zoonotic paramyxoviruses with a broader tropism than most other paramyxoviruses, and can cause severe acute encephalitis
Ribavirin was empirically used during the Nipah virus outbreak but its efficacy is disputed
There are currently no approved effective prophylactic or therapeutic treatments for henipavirus infections

Methodology

Study Type: Review
Sample Size: Not applicable (literature review)
Geographic Focus: Australia, Malaysia
Time Period: 1994-1998

Topics

Henipavirus, Nipah, Hendra, Inhibitors, Antivirals, Pathology, Animal Models

Relevance

This paper is important for understanding the current state of research on Henipaviruses, which have a high public health and economic threat potential.

Source

View the entire paper: File:Nihms343752.pdf