Henipavirus Receptor Usage and Tropism

Authors: Manuscript Author: Olivier Pernet, Manuscript Author: Benhur Lee

Year: 2012

Journal: Curr Top Microbiol Immunol.

DOI: 10.1007/82_2012_222

Summary

This paper reviews the biology of the henipavirus receptors, ephrin-B2 and ephrin-B3, and how their usage relates to henipavirus cell tropism in vitro and in vivo.

Key Findings

• Henipaviruses use ephrin-B2 and ephrin-B3 as viral entry receptors
• These receptors account for the unusual species tropism of henipaviruses

Methodology

• Study Type: Review

Topics

Virology

Relevance

This paper provides insights into the receptor usage and tropism of henipaviruses, which are biosafety level 4 (BSL4) pathogens with high mortality rates in humans. Understanding these aspects can help develop vaccines and therapeutics for these deadly viruses.

Source

View the entire paper: File:Nihms444714.pdf