High Pathogenicity of Nipah Virus from Pteropus lylei Fruit Bats, Cambodia

Authors: Maria Gaudino, Noémie Aurine, Claire Dumont, Julien Fouret, Marion Ferren, Cyrille Mathieu, Olivier Reynard, Viktor E. Volchkov, Catherine Legras-Lachuer, Marie-Claude Georges-Courbot, Branka Horvat

Year: 2019

Journal: Emerging Infectious Diseases

DOI: 10.3201/eid2601.191284

Summary

The paper characterizes a Nipah virus (NiV) isolate from Cambodia in 2003, revealing similar cell permissiveness and replication in both bat and human cell lines. The virus has high pathogenic potential and may provide insight for future NiV outbreaks in Southeast Asia.

Key Findings

CSUR381 is part of the NiV-Malaysia genotype
In vitro studies showed similar cell permissiveness and replication
Conservation of ephrin-B2 and ephrinB3 receptor binding sites, glycosylation site on G attachment protein, editing site in phosphoprotein
CSUR381 induced lethal infections in hamster animal model

Methodology

Study Type: Laboratory-based study
Sample Size: One bat isolate (CSUR381)
Geographic Focus: Cambodia
Time Period: 2003

Topics

Virology, Epidemiology

Relevance

The study provides insights into the pathogenic potential of a Nipah virus isolate, which may aid in better risk assessment for future outbreaks in Southeast Asia.

Source

View the entire paper: File:19-1284.pdf