The Genetic Diversity of Nipah Virus Across Spatial Scales

Authors: Oscar Cortes-Azuero, Noémie Lefrancq, Birgit Nikolay, Clifton McKee, Julien Cappelle, Vibol Hul, Tey Putita Ou, Thavry Hoem, Philippe Lemey, Mohammed Ziaur Rahman, Ausraful Islam, Emily S. Gurley, Veasna Duong, Henrik Salje

Year: 2024

Journal: The Journal of Infectious Diseases

DOI: 10.xxxx/xxxxx

Summary

This paper investigates the genetic diversity of Nipah virus across spatial scales using a comprehensive collection of genomes from bats and humans over 22 years in six countries.

Key Findings

Average of 2.4 co-circulating genetic clusters within any bat roost, rising to 5.5 clusters at areas of 1500–2000 km²
Each genetic cluster occupies an average area of 1.3 million km² (95% confidence interval [CI], .6–2.3 million km²)
In concentrated genomic surveillance sites in Bangladesh and Cambodia, only approximately 15% of overall NiV diversity has been uncovered

Methodology

Study Type: Study Type not explicitly mentioned
Sample Size: N = 257
Geographic Focus: ['6 countries']
Time Period: 1999–2020

Topics

Epidemiology, Virology, Genetics

Relevance

The findings provide valuable insights into the genetic diversity of Nipah virus, which is crucial for understanding its transmission dynamics and developing control strategies.

Source

View the entire paper: File:Jiae221.pdf