View source for Host–Pathogen Interactions Influencing Zoonotic Spillover Potential and Transmission in Humans

'''Authors:''' Beatriz Escudero-Pérez, Alexandre Lalande, Cyrille Mathieu, Philip Lawrence

'''Year:''' 2023

'''Journal:''' Humans. Viruses

'''DOI:''' 10.3390/v15030599

=== Summary ===
This paper reviews key host-pathogen interactions influencing zoonotic spillover potential and transmission in humans, with a focus on the Nipah virus and Ebola virus.

=== Key Findings ===
* Key factors determining spillover potential include cellular and tissue tropism, virulence, and pathogenic characteristics of the pathogen, and the capacity to adapt and evolve within a novel host environment.
* The review highlights an emerging understanding of the importance of steric hindrance of host cell factors by viral proteins using a ‘flytrap’-type mechanism of protein amyloidogenesis for future antiviral therapies against emerging pathogens.

=== Methodology ===
* '''Study Type:''' Review

=== Topics ===
Epidemiology, Virology, Policy

=== Relevance ===
The paper discusses strategies to prepare for and reduce the frequency of zoonotic spillover occurrences in order to minimize the risk of new outbreaks, particularly relevant for Nipah research.

=== Source ===
View the entire paper: [[File:viruses-15-00599.pdf]]