Virology and Pathogenesis: Difference between revisions
Added 75 papers - 2026-02-07T07:47:55.647410 |
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=== [[Improving clinical care of patients in Nipah outbreaks: moving beyond ‘compassionate use’|Improving clinical care of patients in Nipah outbreaks: moving beyond ‘compassionate use’]] === | === [[Improving clinical care of patients in Nipah outbreaks: moving beyond ‘compassionate use’|Improving clinical care of patients in Nipah outbreaks: moving beyond ‘compassionate use’]] === | ||
'''2024''' - The Lancet Regional Health - Southeast Asia | '''2024''' - The Lancet Regional Health - Southeast Asia | ||
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This paper argues for considering the wider socioeconomic consequences of infectious disease events beyond traditional public health sectors. | This paper argues for considering the wider socioeconomic consequences of infectious disease events beyond traditional public health sectors. | ||
=== [[Designing potential siRNA molecules for silencing the gene of the nucleocapsid protein of Nipah virus: A computational investigation|Designing potential siRNA molecules for silencing the gene of the nucleocapsid protein of Nipah virus: A computational investigation]] === | === [[Designing potential siRNA molecules for silencing the gene of the nucleocapsid protein of Nipah virus: A computational investigation|Designing potential siRNA molecules for silencing the gene of the nucleocapsid protein of Nipah virus: A computational investigation]] === | ||
Latest revision as of 02:30, 7 February 2026
2024 - The Lancet Regional Health - Southeast Asia
This paper discusses strategies to improve the clinical care for patients in Nipah outbreaks, focusing on enhancing early case detection, optimizing supportive care, adopting a syndromic approach, and exploring innovative trial designs. The goal is to better equip healthcare systems in Nipah-endemic regions to manage current and future outbreaks.
2022 - Annals of Medicine and Surgery
This paper discusses the recent re-emergence of Nipah virus (NiV) in India's Kozhikode district, causing the death of a 12-year-old boy. The authors aim to suggest recommendations to contain and mitigate the severe impact of the virus on affected populations.
2023 - New Microbes and New Infections
This paper calls for vigilance, collaboration, and preparedness to address the recurrent Nipah Virus outbreaks in Kerala, India.
2025 - New Microbes and New Infections
This paper discusses the challenges posed by Nipah virus, a zoonotic pathogen, focusing on its diverse strains, recurrent outbreaks, diagnostic limitations, and the need for therapeutic advancements.
2024 - New Microbes and New Infections
The paper discusses the emergence of Nipah virus as a global public health threat, with recent outbreaks in Bangladesh raising concerns. There is currently no specific therapeutic intervention for infected individuals.
2019 - One Health
This paper argues for considering the wider socioeconomic consequences of infectious disease events beyond traditional public health sectors.
2022 - Infection, Genetics and Evolution
This paper designs potential siRNA molecules to silence the gene of the nucleocapsid protein of Nipah virus, aiming to combat the virus due to its crucial role in viral replication.
2023 - Infection, Genetics and Evolution
This paper investigates the binding affinity of Nipah virus attachment glycoprotein to host cell receptors Ephrin-B2 and Ephrin-B3 in domestic and peridomestic mammals commonly found in Bangladesh.
2022 - Current Opinion in Virology
This paper reviews the mechanisms that allow fruit bats to control Henipavirus infection while avoiding uncontrollable virus expansion and immunopathology.
2007 - Emerging Infectious Diseases
This paper describes a full genome sequence of Nipah virus from an outbreak in India that caused encephalitis or respiratory symptoms and resulted in five deaths.
2024 - International Journal of Peptide Research and Therapeutics
This paper aims to predict a dual-antigen multi-epitope subunit chimeric vaccine against surface-glycoproteins G and F of Nipah Virus using immunoinformatics analyses.
2018 - Emerging Infectious Diseases
This paper characterizes the complete genomic sequences of Nipah Virus isolates from two patients in Bangladesh in 2008 and partial sequences from three patients in 2010. The sequences were found to be distinct, indicating multiple co-circulating lineages in a localized region over a short time.
2010 - Journal of Virology
This paper introduces a new disease model of acute Hendra Virus infection in African green monkeys and evaluates the effectiveness of Ribavirin treatment.
2023 - Applied Biochemistry and Biotechnology
This paper reviews Nipah virus (NiV), a zoonotic disease causing encephalitis and severe respiratory illness in humans, primarily carried by Pteropus spp. bats. It discusses the need for clinical trials to establish potential treatment regimens.
2022 - J. Chem. Sci.
This paper investigates the molecular mechanism of interaction between Nipah and Hendra virus glycoproteins and human ephrin-B2 and B3 cell surface proteins using computational methods.
2025 - BMC Microbiology
The paper describes the development of a system to generate Nipah virus pseudovirions with uniform incorporation of F and G surface glycoproteins for high-throughput neutralization assays.
2023 - BMC Public Health
This paper explores the phenomenon of superspreading events in the SARS-CoV-2 (COVID-19) pandemic through a systematic review and meta-analysis. It found that a majority of studies reported lower than one for the dispersion parameter k, indicating significant heterogeneity in inter-individual transmission potential.
2016 - Virology Journal
This study identified Nipah virus strain using molecular characterizations from Pteropus hypomelanus in southern Thailand.
2018 - Emerging Infectious Diseases
This paper retrieves Nipah virus sequences from human and bat samples during a 2018 outbreak in Kerala, India, demonstrating the similarity of the virus from humans to that of bats, indicating bats as the source of the outbreak.
2019 - Emerging Infectious Diseases
The paper characterizes a Nipah virus (NiV) isolate from Cambodia in 2003, revealing similar cell permissiveness and replication in both bat and human cell lines. The virus has high pathogenic potential and may provide insight for future NiV outbreaks in Southeast Asia.
2024 - Emerging Infectious Diseases
This paper analyzes the genetic diversity and geographic spread of Henipaviruses, including Hendra and Nipah viruses, using data from National Center for Biotechnology Information Virus and VIRION databases. The study found that bats and shrews are dominant hosts, with key henipavirus hosts in Asia, Australia, and Africa.
2025 - Applied Microbiology and Biotechnology
This paper is a detailed review on Nipah virus, covering its origin and spread, modes of transmission, risk factors, genome, key proteins, pathogenesis, clinical features, diagnostics, and ongoing research for therapies.
2024 - In Silico Pharmacology
The paper aims to develop a subunit vaccine against the Nipah virus (NiV) by analyzing its proteome and predicting T-cell, helper T-cell, and B-cell epitopes using various servers. The predicted high-affinity epitopes were evaluated for antigenicity, toxicity, and allergenicity, and molecular interactions with specific receptors were analyzed.
2024 - BioMed Research International
This paper describes an in silico study that identifies epitopes from the conserved region of NiV proteins and constructs a multiepitope-based vaccine candidate. The final vaccine candidate has a total combined coverage range of 80.53%.
2024 - Not specified in text
This review paper discusses the abilities of SARS-CoV-2 and other neurotropic RNA viruses, including Zika virus and Nipah virus, to cross the blood–brain barrier into the central nervous system. It highlights the role of magnetic resonance imaging (MRI) in assessing presence and severity of brain structural changes in COVID-19 patients and presents new insight into key mutations in SARS-CoV-2 variants that may impact on neuropilin 1 binding and CNS invasion.
2024 - Volume 16 Number 1 (February 2024) 104-113
This paper uses a comparative genomic approach to identify mutations in Nipah virus (NiV) human isolates from Malaysia, Bangladesh, and India.
2024 - Indian J Med Res
The paper develops and evaluates IgM and IgG ELISAs for detecting Nipah virus antibodies in human sera, demonstrating high specificity and sensitivity.
2023 - VIRULENCE
This paper analyzes the genomic characterization, transcriptome, and pathogenicity of a Nipah virus (Indian isolate) using Vero (ATCC® CCL−81™) and BHK−21 cells in a Syrian hamster model.
2025 - Cell
The paper provides insights into the functional and antigenic properties of the Nipah virus receptor-binding protein (RBP) through deep mutational scanning, which helps understand viral evolution and design therapeutics.
2021 - International Journal of Infectious Diseases
This study aimed to characterize the molecular epidemiology and evolution of Nipah virus in Bangladesh.
2022 - Open Veterinary Journal
This review discusses various paramyxoviruses found in rodents, their distribution, transmission, pathogenesis, clinical manifestations, diagnostic methods, and control measures.
2023 - VIRULENCE
This paper reviews the pathogenesis, replication cycle, epidemiology, genomics, and host responses of henipaviruses, including Nipah (NiV), Hendra (HeV), Langya (LayV), Gamak (GAKV), and CedV.
2024 - Emerging Microbes & Infections
Researchers developed and validated a split NanoLuc luciferase NiV glycoprotein (G) biosensor for detecting antibodies in clinical and animal samples. The assay was tested using the WHO’s first international standard for anti-NiV antibodies and more than 700 serum samples from Bangladesh, showing sensitivity and specificity comparable to anti-NiV IgG ELISA performance.
2023 - Biosensors
This paper describes the development of a fluorescent biosensor for detecting Nipah virus RNA using DNAzyme 10–23.
2021 - Science of the Total Environment
This paper suggests that natural resources could be a future source of antiviral therapy for deadly human diseases such as Zika virus disease, Nipah virus disease, Severe acute respiratory syndrome, Coronavirus disease, and Herpes simplex virus infection.
2025 - Front. Cell. Infect. Microbiol.
This paper discusses antivirotics based on defective interfering particles and their emerging concepts and challenges.
2023 - Frontiers in Immunology
This paper reviews the immune correlates of protection for SARS-CoV-2, Ebola, and Nipah virus infections.
2023 - Front. Immunol.
This paper investigates immunological correlates of protection afforded by PHV02, a recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease in the African green monkey model. Neutralizing antibody to Nipah virus is proposed as the principal mediator of protection.
2024 - Front. Microbiol.
This paper reviews the latest advancements in understanding Sosuga Virus (SOSV), a zoonotic paramyxovirus from bats, focusing on its pathogenesis, animal models, and antiviral strategies.
2024 - The Journal of Clinical Investigation
This paper reports on a recombinant vesicular stomatitis virus–based vaccine that provides long-lasting immunity against Nipah virus disease in African green monkeys.
2023 - The Journal of Infectious Diseases
This paper studies the susceptibility and pathogenesis of Nipah virus Bangladesh strain (NiVB) infection in marmosets at biosafety level 4. The study reveals unique transcriptomes in different tissues from infected and control marmosets, particularly in the brainstem of a marmoset that exhibited neurological signs.
2024 - The Journal of Infectious Diseases
This paper investigates the genetic diversity of Nipah virus across spatial scales using a comprehensive collection of genomes from bats and humans over 22 years in six countries.
2024 - The Journal of Infectious Diseases
This paper evaluates the infectivity and pathogenicity of aerosolized Nipah virus (NiV) in Syrian hamsters, demonstrating that they develop similar clinical manifestations to those previously described using liquid inoculum.
2024 - The Journal of Infectious Diseases
A single-dose mRNA vaccine protected up to 70% of Syrian hamsters from lethal Nipah virus challenge, despite animals having suboptimally primed immune responses before challenge.
2024 - Heliyon
This paper synthesizes HiBiT-tagged Nipah virus-like particles for in vitro BSL-2 handling and rapid antibody neutralization studies.
2025 - Cell
The paper determines the cryoelectron microscopy (cryo-EM) structure of the Nipah virus polymerase complex and performs structural, biophysical, and functional analyses to understand features critical for RNA replication and transcription. The findings could aid in the development of antivirals.
2025 - eBioMedicine
The paper explores the effectiveness of defective interfering particles (DIPs) in reducing clinical signs and lethality of henipavirus infection in Syrian hamsters.
2023 - iScience
The study investigates the differential host-immune kinetics associated with SARS-CoV-2 variants during different time periods of Pre-VOC and VOCs (Delta & Omicron). The findings suggest that Omicron infection is marked by a robust type 1 interferon response, which was largely missing during Pre-VOC and Delta waves. The study highlights the eventual adaptation of host to immune activation patterns that interrupt virus evolution with enhanced immune-evasion mutations and counteraction mechanisms.
2019 - Sci Transl Med
The paper tests the efficacy of remdesivir (GS-5734), a broad-acting antiviral nucleotide prodrug, against Nipah virus in African green monkeys. Remdesivir treatment resulted in the survival of all treated animals, while control animals succumbed to the infection.
2024 - Antiviral Res.
Late treatment with remdesivir partially protects African green monkeys from lethal Nipah virus infection, but does not prevent clinical disease or histologic lesions in the brain.
2022 - Science
This paper determines a cryo-electron microscopy structure of the Nipah virus (NiV) attachment glycoprotein (G) homotetrameric ectodomain in complex with the nAH1.3 broadly neutralizing antibody Fab fragment. The results suggest a multi-pronged therapeutic strategy against these deadly pathogens.
2011 - Infect Disord Drug Targets
This paper reviews the unique features of henipavirus infections, and discusses different strategies and animal models that have been developed to identify and test potential drugs for preventing or treating henipavirus infections.
2012 - Semin Cell Dev Biol
This paper reviews recent progress in the study of henipavirus entry, particularly the identification of ephrins as their entry receptors, and the structural characterization of the ephrin/Henipa-G interactions.
2012 - Curr Top Microbiol Immunol.
This paper reviews the biology of the henipavirus receptors, ephrin-B2 and ephrin-B3, and how their usage relates to henipavirus cell tropism in vitro and in vivo.
2022 - Not specified in the text
This paper studies a new variant of Hendra virus (HeV-g2) that has unprecedented genetic divergence and identifies it in horses and flying fox species in Australia. The researchers demonstrate that HeV-g2 shares a conserved receptor tropism with prototypic HeV and can be potently neutralized by a panel of monoclonal antibodies recognizing the G and F glycoproteins.
2024 - Not specified in the text
The paper discusses a study using a recombinant vesicular stomatitis virus (rVSV) vaccine to protect nonhuman primates from lethal Nipah virus disease, with protection observed in monkeys vaccinated 7 days prior to NiV exposure and 67% of animals vaccinated 3 days before challenge.
2024 - Journal Name not provided in the text
This paper investigates a newly discovered pathogen, Feline Morbillivirus (FeMV), affecting domestic cats. The study determines the complete sequence of FeMV and reveals unique characteristics that differ from other morbilliviruses. FeMV uses a different protease to furin for processing its fusion glycoprotein and employs feline CD150 as a cellular receptor, making it distinct among morbilliviruses. The study also develops a reverse genetics system for FeMV and demonstrates that it causes an acute morbillivirus-like disease in cats.
2016 - PLoS Negl Trop Dis
This paper investigates the differences in transmission of Nipah viruses between Malaysia and Bangladesh in ferrets, suggesting a contributory mechanism for increased transmission of NiV-BD compared to NiV-MY due to higher levels of virus replication in respiratory tract tissues.
2018 - PLoS Negl Trop Dis
This paper investigates the effects of aerosol exposure to intermediate size Nipah virus particles on African green monkeys, mimicking potential human exposure, and finds that it induces neurological disease.
2025 - Journal of Cheminformatics
This paper presents the Nipah Virus Inhibitor Knowledgebase (NVIK), a resource for NiV drug discovery containing manually curated NVIs with IC50/EC50 values in the nanomolar range. The authors prioritised top 10 NVIs based on robustness of assays, physicochemical properties and their toxicity profiles.
2024 - Microbial Genetics | Methods and Protocols
This study developed a culture-independent, high-throughput sequencing protocol for Nipah virus using the Oxford Nanopore Technology platform, suitable for resource-limited settings.
2016 - Scientific Reports
This paper investigates the pathogenic differences between two strains of Nipah virus (NiV), Malaysia (NiVM) and Bangladesh (NiVB), by exposing African green monkeys to each strain. The findings suggest that NiVB is more pathogenic, with a higher mortality rate and more severe histopathology in infected animals compared to NiVM.
2023 - Annals of Epidemiology
The study reviews research on individuals who have transmitted pathogens causing SARS, MERS, or COVID-19 to at least nine other people. It found that the most typical super-spreader is a male age 40+, with SARS and MERS super-spreaders often symptomatic and middle-aged/older adults who had a high mortality rate. In contrast, COVID-19 super-spreaders tended to have mild disease and were any adult age.
2021 - Tropical Medicine and Infectious Disease Review
This paper reviews the evolution of Nipah virus infection, its epidemiology, microbiology, and the therapeutic agents and vaccines in development.
2023 - Tropical Medicine and Infectious Disease
This paper describes the first confirmed case of vertical transfer of humoral immunity against Nipah virus from a mother to her newborn in Bangladesh.
2021 - Virus Evolution
Researchers generated 35 additional full-length genomic sequences of Nipah virus directly from human specimens and viral isolates in Bangladesh to study its temporal and geographic evolution. They observed two distinct clades that intermingled over time and space, but did not find significant branch or site-specific selection except for a single site in the Henipavirus L polymerase.
2021 - Viruses
This paper discusses the need for a transdisciplinary approach to prevent the spillover of henipaviruses, a group of viruses derived from bats that frequently cross species barriers and can cause high human mortality.
2022 - Viruses
This review provides an overview of the pathogenicity mechanisms and interactions between Henipaviruses (Nipah and Hendra) and their hosts in various species including bats, pigs, horses, humans, and experimental animal models. The findings could aid in developing new therapeutic strategies against these re-emerging viruses.
2022 - Viruses
The paper evaluates the efficacy of various physical and chemical inactivation methods for Nipah virus (NiV) in infected cells, supernatants, and organs.
2022 - Viruses
This paper describes the formation of ordered intracellular structures during Nipah virus infection.
2022 - Viruses
This paper reports the discovery of a novel henipa-like virus from opossums in a forest fragment area in Brazil, emphasizing the importance of further studies to characterize this virus and clarify its ecology, impact on public health, and its relationship with didelphid marsupials and henipaviruses.
2023 - Viruses
This paper reviews various animal models used for studying Henipavirus (Hendra virus and Nipah virus) pathogenesis and medical countermeasures.
2024 - Viruses
This paper reviews the available structural information on Henipavirus glycoproteins, which are important for understanding viral entry and developing vaccines and therapies.
2015 - Virus Research
This paper discusses how bats are reservoirs for several severe emerging infectious diseases, including Ebola virus, SARS coronavirus, MERS coronavirus, Nipah virus, and Hendra virus.